Abstract
Serial plasma growth hormone (GH) values in four normal women were found to fluctuate widely during the day with peak values as high as 32 mμg/ml. The present study established two points: (1) patients with Cushing's syndrome lack normal spontaneous peaks in plasma GH and (2) normal subjects treated for two weeks with prednisone in doses of 15 mg. per day (roughly equivalent to the amount of cortisol secreted in Cushing's syndrome) showed no significant diminution in their spontaneous plasma GH peaks. It is possible that the chronicity, the constancy, and the severity of glucocorticoid excess might all be factors in abolishing the plasma GH peaks in Cushing's syndrome.
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