Abstract
Objectives:To explore the effect of glucocorticoids combined with disease modifying anti-rheumatic drugs in the treatment of symptoms in patients with rheumatoid arthritis.Methods:Medical records of patients with rheumatoid arthritis treated in the Rheumatology and Immunology Department of Yiwu Central Hospital from March 2020 to March 2021 were selected. A total of 38 patients were treated with disease modifying anti-rheumatic drugs Group-I and 44 patients were treated with disease modifying anti-rheumatic drugs and glucocorticoids Group-II. The symptom improvement of the two groups were compared and analyzed Serological indexes and adverse reactions.Results:Swollen joint counts (SJC), tender joint counts (TJC), rheumatoid arthritis disease activity evaluation form (DAS28) score, erythrocyte sedimentation rate, levels of ESR, C-reaction protein (CRP) and rheumatoid factor (RF) of Group-II patients were lower than those in Group-I (P<0.05). The adverse reaction rate in Group-II patients was 12.20%, which was similar to that of Group-I patients. There was no significant difference in 9.76% of the patients (P>0.05).Conclusion:The combination of glucocorticoids and disease modifying anti-rheumatic drugs in the treatment of patients with rheumatoid arthritis is safe can further improve their symptoms and serological indexes, and will not lead to increased adverse reactions.
Highlights
Rheumatoid arthritis is a common systemic autoimmune disease that mainly manifests as systemic arthritis
The diagnosis was made according to the diagnostic criteria of rheumatoid arthritis proposed by the American Society of Rheumatology (ACR);[5]
On the day of admission, there was no significant difference in Swollen joint counts (SJC), tender joint counts (TJC) and DAS28 scores between the two groups (P>0.05)
Summary
Rheumatoid arthritis is a common systemic autoimmune disease that mainly manifests as systemic arthritis. Its pathological characteristics are mainly vasculitis and synovitis. Rheumatoid arthritis can lead to bone destruction, and may affect ligaments, tendons, muscles and other tissues around the joint, resulting in decreased joint stability and joint deformity and dysfunction.[1]. Vasculitis can affect the surrounding organs and tissues, including lungs, which can lead to life-threatening complications of pulmonary interstitial fibrosis.[2]. The standardized systematic treatment of rheumatoid arthritis has been continuously emphasized in clinic. In addition to symptom relief and improvement of
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