Abstract
Background Changes of the coagulation system are promoted by serious infectious or noninfectious diseases, surgical procedures, and exogenous substances, including drugs. This study aimed to assess the effect of methylprednisolone pulses on selected parameters of the coagulation system. Methods The study group consisted of patients suffering from multiple sclerosis, thyroid orbitopathy, or sudden sensorineural hearing loss. 48 patients and 20 healthy volunteers were examined. The hemostatic parameters: activity of coagulation factors (VIII, IX, and XI), antithrombin activity, protein C and S activity, and concentration of soluble tissue factor were analyzed at baseline and after 3 g and 5 g of methylprednisolone administration. Results A statistically significant increase was noted in the activity of all the studied plasma coagulation factors, plasma coagulation inhibitors (except protein S activity), and the concentration of soluble tissue factor after methylprednisolone administration. Conclusion The glucocorticoids administered in the intravenous pulses of methylprednisolone shift the balance toward thromboembolic complications.
Highlights
Glucocorticoids (GCs) are one of the most commonly used classes of drugs worldwide
A total of 48 patients were qualified for the study group, and 20 people were recruited to the control group
The study group did not differ significantly from the control group in terms of age, Body mass index GCs (BMI), and gender. e mean score on the Padua scale used for assessing thromboembolic risk did not differ significantly between the study and control groups (0.458 vs. 0.2, P 0.09), and all the observations (100%) were categorized as low thromboembolic risk
Summary
Changes of the coagulation system are promoted by serious infectious or noninfectious diseases, surgical procedures, and exogenous substances, including drugs. is study aimed to assess the effect of methylprednisolone pulses on selected parameters of the coagulation system. Is study aimed to assess the effect of methylprednisolone pulses on selected parameters of the coagulation system. E study group consisted of patients suffering from multiple sclerosis, thyroid orbitopathy, or sudden sensorineural hearing loss. 48 patients and 20 healthy volunteers were examined. E hemostatic parameters: activity of coagulation factors (VIII, IX, and XI), antithrombin activity, protein C and S activity, and concentration of soluble tissue factor were analyzed at baseline and after 3 g and 5 g of methylprednisolone administration. A statistically significant increase was noted in the activity of all the studied plasma coagulation factors, plasma coagulation inhibitors (except protein S activity), and the concentration of soluble tissue factor after methylprednisolone administration. E glucocorticoids administered in the intravenous pulses of methylprednisolone shift the balance toward thromboembolic complications Conclusion. e glucocorticoids administered in the intravenous pulses of methylprednisolone shift the balance toward thromboembolic complications
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