Abstract
Gliotoxin, a fungal metabolite, inhibited acetolactate synthase (ALS) activity in cultured tobacco cells. The cell growth was inhibited by gliotoxin and the inhibition was reversed by casamino acids. In whole plants, gliotoxin specifically inhibited root growth. This effect was also overcome by valine, leucine and isoleucine. These results suggested that gliotoxin interferes with the production of branched-chain amino acids by inhibiting ALS.
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