Abstract
1. 1. The cardiac functional response to extracellular Ca 2+ in isolated working hearts was evaluated in streptozotocin-induced diabetic rats treated or not treated with gliclazide. 2. 2. Gliclazide treatment of diabetic rats allowed a partial recovery of the body weight decrease, but not of the hyperglycemia nor insulinopenia. 3. 3. The cardiac mechanical response of diabetic rats was altered, especially at high Ca 2+ concentration, and 6-week gliclazide treatment restored the dysfunction close to the control values. 4. 4. The results suggest that gliclazide treatment restores the cardiac function of chronic diabetic rats partly through modulating the Ca 2+ metabolism.
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