Abstract
Oxidative stress is involved in the development and progression of otitis media (OM). In this study, we investigated the effect of Ginkgo leaf parenteral solution on blood and cochlea antioxidant and immunity indexs in OM rats. In OM model rats, blood and cochlea malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) levels were significantly increased, whereas antioxidant enzymes activities (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR)) were significantly decreased compared with normal rats. Treatment with Ginkgo leaf parenteral solution restored the altered parameters in a dose-dependent manner. We conclude that Ginkgo leaf parenteral solution confers protection against oxidative injuries in OM rats by increasing activities of antioxidants and immunity, suggesting a potential drug for the prevention and therapy of OM.
Highlights
Acute otitis media (AOM) occurring early in infancy may be an important predictor of later morbidity, including psychological and educational difficulties
The present study was performed to investigate the effect of Ginkgo leaf parenteral solution on nitric oxide, antioxidant enzymes and immunity indexes in rats with otitis media
There was a significant increase in the concentration of MDA and nitric oxide (NO) in tissues of OM rats (Group II)
Summary
Acute otitis media (AOM) occurring early in infancy may be an important predictor of later morbidity, including psychological and educational difficulties. Molecules 2011, 16 component, including rheumatoid arthritis, atherosclerosis [1], pulmonary emphysema, inflammatory bowel disease, and periodontal disease [2]. They are believed to play a role in stroke, e.g., myocardial infarction [3], and cataracts [4], as well as the degenerative processes associated with aging [5]. Several studies have concentrated on the role of free oxygen radicals and nitric oxide in the development of myringosclerosis in traumatized tympanic membranes and otitis media with effusion [19,20,21]. The present study was performed to investigate the effect of Ginkgo leaf parenteral solution on nitric oxide, antioxidant enzymes and immunity indexes in rats with otitis media
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