Abstract
BackgroundGestational diabetes mellitus (GDM) is one the most common complications of pregnancy. The present work aimed at investigating the effect of ginger on the blood glucose level of GDM women with impaired glucose tolerance test (GTT).MethodsThis randomized double-blind placebo-controlled clinical trial was performed on the total of 70 women with GDM, who were in 24–28 weeks of pregnancy with impaired GTT from 2015 to 2016. For this purpose, the women were assigned to two groups of ginger or placebo. The ginger group received 126 tablets of ginger, and the placebo group received 126 tablets of placebo for six weeks. The serum Blood Sugar 2 h post-prandial (BS2hpp), Fast Blood Sugar (FBS) and insulin, as well as Homeostasis Model Assessment (HOMA) index were analyzed before and six weeks after intervention.ResultsThe mean of FBS (P = 0.04), fasting insulin (P = 0.01), and HOMA index (P = 0.05) was reduced significantly in the ginger group six weeks after intervention in comparison to the placebo group. But the mean of BS2hpp did not show any significant reduction in the two groups (P > 0.05(.ConclusionsOral administration of ginger tablet improved FBS, serum insulin and HOMA index in the women with GDM; however, it could not reduce their BS2hpp level.The trial has been registered in the Iranian Registry of Clinical Trials (IRCT2015090523897N1).
Highlights
Gestational diabetes mellitus (GDM) is one the most common complications of pregnancy
If the Fast Blood Sugar (FBS) level was higher than 92 mg/dl, first hour post-prandial blood glucose level was higher than 180 mg/dl and 2 h post-prandial was higher than 153 mg/dl, pregnant women were considered to have GDM According to a computer-generated list of random number groups, each woman was randomly allocated to each arm
Ginger treatment significantly reduced the levels of FBS, serum insulin and Homeostasis Model Assessment (HOMA) index comparing to the placebo group but there was no significant difference between the two groups in Blood Sugar 2 h post-prandial (BS2hpp) after the treatment by the ginger tablets (Table 2)
Summary
Gestational diabetes mellitus (GDM) is one the most common complications of pregnancy. The present work aimed at investigating the effect of ginger on the blood glucose level of GDM women with impaired glucose tolerance test (GTT). Impaired glucose tolerance occurring for the first time during pregnancy is called Gestational Diabetes Mellitus (GDM). GDM prevalence of 1–14% has been reported in different studies [1]. The medicinal features attributed to ginger are anti-arthritic, anti-migraine, antithrombotic, anti-inflammatory, anti-nausea, antivomiting, hypolipidemic and analgesic properties [5, 6]. It has been reported that ginger is a hypoglycemic food adjunct in both animals and humans [6,7,8] In recent years, ginger has been used for the treatment of Type 2 Diabetes (T2D) in human subjects [9]
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