Abstract
Effect of Ghrelin on Viability, Proliferation, and Apoptosis in Human Granulosa Cells, In Vitro
Highlights
Background and ObjectivesGhrelin is a peptide hormone that was initially derived from stomach and introduced as an endogenous ligand for the growth hormone secretagogue receptor
In this experimental-laboratory study, granulosa cell samples were collected from patients with tubal or male infertility factors, who were treated with IVF or ICSI for the first time
The cells were cultured in a medium containing DMEM-F12 with FBS 10% and penicillin 1% and streptomycin, ghrelin was tested in cells at concentrations of 100, 250, 500, 1000, and 10000 pm for 24 hours
Summary
Ghrelin is a peptide hormone that was initially derived from stomach and introduced as an endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is fundamentally involved in regulation of nutrition and energy homeostasis in the body. It has been shown that ghrelin has an important role in fertility in women. The purpose of the present study was to assess the effect of ghrelin on viability, growth, and apoptosis of human granulosa cells culture in vitro
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