Abstract
Essential oils have been advertised endlessly to be very beneficial for the health of humans, and an extensive amount of research examines the validity of such claims. In contribution, the current study evaluates the neuroprotective properties of Citronellol and Geraniol essential oils (EOs). In relationship to the biophysical gating properties of different the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits, the EOs were administered to HEK293 (Human embryonic kidney 293) cells and examined for any inhibition and effect on desensitization or deactivation rates, using whole-cell patch-clamp electrophysiology. Our results demonstrated the highest levels of inhibition from Citronellol oil by four-fold on all AMPARs subunits. Likewise, Geraniol oil had a similar inhibiting impact on the receptors, and both oils decreased the desensitization and deactivation rates of the inhibited receptors. Thus, the examined EOs of this study portray neuroprotective qualities by targeting AMPARs activation and reducing desensitization and deactivation rates. Finally, the results of the current study entail a better understanding of AMPARs, provides a natural template for future drug synthesis to treat neurological diseases associated with excessive AMPAR activation, and offers a possible mechanism by which these essential oils deploy their ‘calming’ effect.
Highlights
Essential oils (EOs) are usually extracted from plants and are used for aromatherapy, which is an alternative medicine that demonstrates the healing effect to the aromatic compounds presented in the oil [1,2]
The results of the current study entail a better understanding of amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), provides a natural template for future drug synthesis to treat neurological diseases associated with excessive AMPAR activation, and offers a possible mechanism by which these essential oils deploy their ‘calming’ effect
To inquire direct effects of the essential oils on amplitude generated by AMPARs, Heterologous expression (GluA1/2 and GluA2/3) and Homologous expression of GluA1 and GluA2 subunits in expression (GluA1/2 and GluA2/3) and Homologous expression of GluA1 and GluA2 subunits in
Summary
Essential oils (EOs) are usually extracted from plants and are used for aromatherapy, which is an alternative medicine that demonstrates the healing effect to the aromatic compounds presented in the oil [1,2]. Many EOs are currently being presented to showcase a wide range of benefits; two important EOs are the Citronellol and Geraniol oils. Geraniol oil is composed of different extracted molecules from the essential oils of various plants, including rose, geranium, and palmarosa species [4,5,6,7]. Geraniol is composed of a combination of plants, its health benefits are of similar to those observed by Citronellol oil [5,6,7].
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