Abstract
Although caffeine is the world's most popular stimulant, used in both athletic and cognitive contexts, its effects vary widely between individuals. In athletics, caffeine effects depend on dose but may include increases in lipolysis, pain tolerance, and time to exhaustion. While the effects of caffeine on cognitive performance are mixed, caffeine consumption has been linked to increased performance on visual processing tasks and reaction time tasks. Despite the evidence supporting the beneficial effects of caffeine on athletic and cognitive performance, variation in genes related to caffeine metabolism and mechanism of action may moderate its performance‐enhancing effects. For example, a single nucleotide polymorphism (rs762551) of the gene for the liver enzyme CYP1A2 has been reported to influence caffeine outcomes, with “slow” metabolizers having reduced benefits of caffeine during exercise and increased risk of heart attack. Similarly, a single nucleotide polymorphism (rs5751876) of the adenosine receptor gene ADORA2A has been reported to modulate caffeine consumption habits, caffeine‐induced anxiety, and the ergogenic effects of caffeine. In this study, 12 collegiate distance runners were genotyped at CYP1A2 and ADORA2A loci. To assess the effects of caffeine on athletic and cognitive performance, participants underwent two treadmill exhaustion tests and two cognitive battery tests, with one trial being under the influence of low dose caffeine and the other a placebo trial. This work may contribute to a better understanding of the variable effects of caffeine consumption on athletic performance, as well as inform the timing and use of caffeine for optimal performance enhancement.Support or Funding InformationSupported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM0103423.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
