Abstract
Extracellular ATP has been previously reported to induce cell retraction and stimulate DNA synthesis in human Chang liver cells via phosphoinositide (PI) signal transduction. The ATP-treated cell assumes a rounded morphology and is tethered to the substratum by microvillous anchors as demonstrated in this study by scanning electron and confocal microscopy. The addition of 0.5 mM genistein, which is known to completely abolish extracellular ATP-stimulated DNA synthesis in Chang liver cells, did not inhibit ATP-induced cell rounding. The results suggest that the seemingly conjoint responses of ATP-stimulated DNA synthesis and cell rounding could be dissociated.
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