Abstract
BackgroundGlobal literature describes differences in the incidence of gastric cancer among populations. For instance, Europeans have lower incidence rates of gastric cancer in relation to Latin and Asian populations, particularly Korean and Japanese populations. However, only a few studies have been able to verify the occurrence of gastric cancer in admixed populations with high interethnic degree mix, such as the Brazilian Amazon region.ResultsWe observed an increase in European ancestry in the control group compared to the case group (47% vs. 41%). Using increments of 10%, compared to categorical distribution of European ancestry in the sample, we found a difference in the contribution between cases and controls (p = 0.03). Multiple logistic regression was performed to determine the influence of European ancestry in susceptibility to gastric cancer in the sample. According to the adopted model, for each 10% increase in European ancestry, there is a 20% decrease chance of developing gastric cancer (P = 0.0121; OR = 0.81; 95% CI 0.54–0.83).ConclusionOverall, the results suggest that a greater contribution of European ancestry can be a protective factor for the development of gastric cancer in the studied Amazon population. It can help to establish protocols able to predict susceptibility to gastric cancer in admixed populations.
Highlights
Global literature describes differences in the incidence of gastric cancer among populations
The results were statistically significant between the case and control groups regarding the following variables: age (P < 0.001), sex (P < 0.001) and European ancestry (P = 0.001)
The results revealed that there was a higher contribution of European ancestry in the control group compared to the case group (47% vs. 41%)
Summary
Global literature describes differences in the incidence of gastric cancer among populations. Europeans have lower rates of gastric cancer incidence when. In this context, it is conceivable that heterogeneity among populations and different genetic ancestries can contribute to the varying levels of susceptibility to cancer development. It is conceivable that heterogeneity among populations and different genetic ancestries can contribute to the varying levels of susceptibility to cancer development This is especially important in admixed populations, such as the Brazilian population, which is known to be one of the most heterogeneous populations in the world, with contributions from three main parental groups: Amerindian, European and African [7,8,9].
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