Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging

Karina Nava Andrade,José Antonio Rivera Mayorga,Gregorio Guadalupe Carbajal Arízaga

doi:10.3390/pr8040462

Karina Nava Andrade, José Antonio Rivera Mayorga + Show 1 more

Open Access

https://doi.org/10.3390/pr8040462

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Journal: Processes	Publication Date: Apr 14, 2020
Citations: 9	License type: CC BY 4.0

Affiliation: University of Guadalajara

Abstract

In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.

Highlights

Cancer is a primary public health problem worldwide, and effective cancer treatment depends on timely detection
Magnetic resonance imaging (MRI) is a non-invasive diagnostic modality that allows the detection of soft tissue disorders using non-ionizing radiation [1]
We describe the synthesis and characterization of GdDy-doped layered double hydroxide (LDH) as well as the influence of lanthanides concentration on MRI contrast

Summary

Introduction

Cancer is a primary public health problem worldwide, and effective cancer treatment depends on timely detection. Magnetic resonance imaging (MRI) is a non-invasive diagnostic modality that allows the detection of soft tissue disorders using non-ionizing radiation [1] In this technique, the water protons that constitute the tissues are excited by the application of a magnetic field and radiofrequency energy. The variation in proton density between tissues is small, but the use of contrast agents improves the MRI sensitivity and specificity for an accurate diagnosis [4]. Gadolinium chelates, such as Gadovist and Magnevist, are widely used as MRI contrast agents [5]

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