Abstract
γ-Guanidinobutyramide has been shown to reduce blood urea levels in experimental animals and humans by an extra-renal mechanism. The effect of this compound on the activity of urea cycle enzymes in rat liver has been investigated by in vitro and in vivo studies. Evidence of M in vitro inhibition ofargininosuccinate synthetase activity has been obtained. It is, however, unlikely that the reduction of blood urea observed after therapeutic exhibition of the drug is due to urea cycle enzyme inhibition.
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