Abstract
Gamma irradiation is used as an efficient method for decontamination of some foodstuffs and herbal medicines. Several studies have shown that low to moderate doses of gamma irradiation do not alter the chemical composition and biological activities of herbal medicine; however, some changes in herbal composition, appearance or properties have been observed in another studies, and this remains controversial. The present study aimed to evaluate the effect of gamma irradiation on the biological activity and the content of bioactive compounds of Cuscuta chinensis L. extract. The dose of 5 kGy was studied for decontamination. The results of the in vitro study showed that the cytotoxic effects on A549 and HT-29 cell lines were improved without any alteration of cytotoxicity on normal cell line. Also, acute oral toxicity of the extract did not change according to in vivo study. However, due to the significant reduction of total phenol and flavonoids contents by 12% and 18% respectively, the improvement of cytotoxic properties maybe due to the formation of new active compounds, the identification of which requires further studies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
