Effect of gadolinium contrast medium administration on susceptibility-weighted imaging of the canine brain.

Abstract

Susceptibility-weighted imaging (SWI) is a gradient echo (GE) MRI sequence. Intravenous administration of gadolinium (Gd) may affect GE images, but its effect on SWI has not been investigated in veterinary medicine. This cross-sectional prospective study evaluated the effects of Gd on SWI. Seventy-one dogs that underwent brain MRI were included and distributed in two groups. Susceptibility-weighted imaging was performed pre- and postcontrast, obtained immediately after Gd administration (Group A: n=35) or delayed (Group B: n=36; median delay 19.9 min). Pre- and post-Gd SWI were analyzed for signal intensity changes in the lentiform nuclei of gray matter (GM), in the centrum semiovale of white matter (WM), and in brain lesions. No difference in GM signal intensity was identified in either group between pre- and postcontrast images (Group A, P=.395; Group B, P=.895). In group A, WM signal intensity was lower in pre- than post-Gd sequences (P=.019). Brain lesions were identified in 30/71 (41%) cases; the signal intensity of intracranial lesions was significantly lower in pre- than post-Gd images in both groups (P<.001); the number of lesions influenced the difference in signal intensity in group B (P=.043). Susceptibility artifacts did not change in appearance between pre- and postcontrast images in either the normal brain or in parenchymal lesions. In conclusion, Gd may modify the signal intensity of WM and brain lesions but does not affect the susceptibility artifacts and does not interfere with SWI interpretation.