Abstract
Background: The most common type of neuropathy in adults is carpal tunnel syndrome (CTS) which is caused by compression of the median nerve at the wrist.
 Methods: This quasi-experimental study was conducted to determine the efficacy of gabapentin on nerve conduction studies in patients with mild CTS. The patients with mild CTS were randomly allocated into two groups. Group A received naproxen alone (500 mg/day, orally) while group B received both gabapentin (100-300 mg) and naproxen (500 mg/day, orally) for two months. Sensory nerve conduction velocity (SNCV) and distal motor latency (DML) were performed at baseline and two months after treatment.
 Results: There were no significant differences between the two groups with regards to the outcome parameters before initiation of intervention. The SNCV and DML showed no significant improvements in group A (p>0.05), whereas for group B the SNCV and DML of the median nerve were significantly improved at two months after treatment (p<0.001).
 Conclusion: Gabapentin was found to be effective for SNCV and DML in patients with mild CTS over a two-month period.
Highlights
The most common type of neuropathy in adults is carpal tunnel syndrome (CTS) caused by compression of the median nerve at the wrist
This study aims to evaluate the efficacy of gabapentin on sensory nerve conduction velocity (SNCV) and distal motor latency (DML) in patients with mild CTS
Our study shows the efficacy of gabapentin on improving Sensory nerve conduction velocity (SNCV) and DML in patients with mild CTS
Summary
The most common type of neuropathy in adults is carpal tunnel syndrome (CTS) caused by compression of the median nerve at the wrist. A higher prevalence was reported in women and in manual workers (Tseng et al 2012) Some modalities such as conservative treatment, topical injections and surgery have been used for treatment of CTS (Jin et al 2012). Some modalities like local corticosteroid injection (Deniz et al 2012) and surgical decompression can significantly improve nerve conduction studies. Hui et al suggested that surgical decompression resulted in greater improvement in median nerve conduction velocity than a single injection of steroid (Hui et al 2005). The SNCV and DML showed no significant improvements in group A (p>0.05), whereas for group B the SNCV and DML of the median nerve were significantly improved at two months after treatment (p
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