Abstract
Pretreatment of rats in vivo with γ-aminobutyric acid (GABA) agonists and drugs which increase GABA levels in brain leads to an increased affinity of [ 3H]diazepam binding sites in rat cerebral cortex. These drugs include amino-oxyacetic acid, muscimol, γ-butyrolactone and β-( p-chlorophenyl)-GABA; pentobarbital and thiosemicarbazide are without major effect. Bicuculline and picrotoxin (at high concentrations) reverse this increase in [ 3H]diazepam binding site affinity.
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