Effect of GABA derivatives on the rate of thrombus formation, platelet aggregation, and plasma coagulation capacity in rats with experimental gestosis.

I N Tyurenkov,V N Perfilova,I S Mokrousov,L B Reznikova,V I Karamysheva,L I Mikhailova,O S Vasil’Eva,V M Berestovitskaya

doi:10.1007/s10517-014-2726-3

Effect of GABA derivatives on the rate of thrombus formation, platelet aggregation, and plasma coagulation capacity in rats with experimental gestosis.

I N Tyurenkov, V N Perfilova + Show 6 more

https://doi.org/10.1007/s10517-014-2726-3

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Journal: Bulletin of Experimental Biology and Medicine	Publication Date: Nov 29, 2014
Citations: 5

Affiliation: Volgograd State Medical University

#Rate Of Thrombus Formation #Degree Of Platelet Aggregation + Show 8 more

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Abstract

Experimental gestosis induced by replacement of drinking water with 1.8% NaCl promoted hypercoagulation, increased the rate and degree of platelet aggregation, and reduced clotting time in pregnant females. GABA derivatives, compounds RGPU-151, RGPU-152, and phenibut normalized parameters of hemostasis and platelet aggregation and the rate of thrombus formation in the animals. The efficiency of the test substances did not significantly differ from that of the reference drug sulodexide.

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