Abstract
Furosemide was administered by intraperitoneal injection and intracochlear perfusion. The peak-to-peak amplitude of the cochlear microphonic at high sound intensities was reduced however the drug was administered. After a period of time ranging from 1-4 h following drug application, cochleae were fixed and prepared for scanning electron microscopy to examine the hair cells. Changes in the hair bundles from basal turns tended to be more extensive than those of more apical turns. Initially there was an increase in the granularity of the surface of the stereociliary membrane and a tendency for cross-links to swell, stretch and break. Later, the surface texture of stereocilia became smoother than normal, and hair cells in the basal turns showed extensive erosion and fracture of cross-links. Tip links could survive even when extensively stretched. It is possible that the morphological changes in stereocilia reported here do not arise from direct actions of furosemide, but indirectly, from perturbations of the ionic composition of cochlear fluids induced by effects of the drug upon the stria vascularis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
