Abstract
Background: Toxicity due to drugs used for neoplastic disorders is documented in previous studies. Cyclophosphamide (CP) is a widely used as anticancer drug, which could cause toxicity of normal cells through its toxic metabolites. The fullerene family, especially Fullerene C60 nanoparticles (NPs) can be utilized in many and different biological fields. We evaluated the protective role of Fullerene C60 (NPs) in the toxicity induced by cyclophosphamide. Methods: The activities of serum Liver marker enzymes; alanin amino transferase (ALT) and aspartate amino transeferase (AST), alkaline phosphatase (ALP). T. protein, Albumin, serum heart marker enzymes; Lactate dehydrogenase (LDH) and creatinine phosphokinase (CK) were determined. Results: Toxicity of the organs like heart, and liver was proved from increases of ALT, AST, ALP, LDH and CK values and a decrease in T. protein and Albumin in cyclophosphamide (200 mg/kg a single dose) administered rats, Fullerene C60NPsdissolved in olive oil (0.8 mg/ml) oral treatment will show enhancement against toxicity induced by (CP)at a dose of 4 mg/kg body weight daily for 10 days. Conclusion: In this study, we wish to report that, the in vivo treatment of Fullerene C60 (NPs) was improved the biochemical changes caused by cyclophosphamide-induced toxicities. These results have importance in the fields of medicine. This may open the way for the biomedical applications of C60in treatment of cancer, neurodegenerative disorders, and ageing.
Highlights
Among these nanoscale chemical structures, fullerenes represent an important source of the biocompatible molecules because of their capacity to be in contact with cells and biological tissues without altering their behaviour
After 10 days of C60-olive oil treatment after a single dose of CP, there were a significant decrease (p
Effect of fullerene C60 on the level of heart marker enzymes As illustrated in Figs. 6 & 7 administrated with C60-olive oil for 10 respectively, the control group showed a days only showed a significant decrease highly significant increase (p
Summary
Among these nanoscale chemical structures, fullerenes represent an important source of the biocompatible molecules because of their capacity to be in contact with cells and biological tissues without altering their behaviour (yang et al, 2007). The fullerene family, and especially C60, has very appealing photo-electro-chemical and physical properties, which can be exploited in many and different biological fields (Bosi et al, 2003). Elshater et al. Toxicity due to drugs used for neoplastic disorders is documented in previous studies. Cyclophosphamide (CP) is a widely used as anticancer drug, which could cause toxicity of normal cells through its toxic metabolites. The fullerene family, especially Fullerene C60 nanoparticles (NPs) can be utilized in many and different biological fields. We evaluated the protective role of Fullerene C60 (NPs) in the toxicity induced by cyclophosphamide
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