Abstract
Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology. The effect of pristine water-soluble fullerene C60 on ATPase activity and superprecipitation reaction of rabbit skeletal muscle natural actomyosin has been revealed, namely an increase of actomyosin superprecipitation and Мg2+, Са2+– and K+-ATPase activity by fullerene was investigated. We conclude that this finding offers a real possibility for the regulation of contraction-relaxation of skeletal muscle with fullerene C60.
Highlights
Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology
Molecular docking (MD) demonstrates the binding of fullerene C60 with actomyosin complex in the active site of myo sin (Fig. 2)
The calculated energy parameters for the actomyosin+fullerene C60 system are shown in Table
Summary
Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology. The effect of fullerene C60 on the actomyosin ATPase activity, which is crucial to the contractile mechanism, is not es tablished. The aim of this investigation was to measure the effect of fullerene C60 in different concentrations on ATPase activity and superpre cipitation of rabbit skeletal muscle actomyosin.
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