Effect of FSH‐SP on inhibition winkle formation, melaningenesis, and promoting skin hydration in UVB‐irradiated HRM‐2 hairless mice

Abstract

Skin is important organ to protect against dangerous external factors including bacteria, chemicals, and UV irradiation. UVB is directly induced destruction in skin epidermis barrier by damaging DNA. Expose to UVB can lead to low skin hydration, winkle formation and melanogenesis. The aim of this study was to investigate the effect of FSH‐SP to protect skin barrier in HRM‐2 hairless mice induced UVB irradiation 150 mJ/cm2 three times a week for 6 weeks. The groups divided PL (FSH‐SP 100 mg/kg b.w.) and PH (FSH‐SP 200 mg/kg b.w.). We examined histopathological experiment about skin damage including changes in skin thickness, melanin pigmentation and winkle formation. Also, we experimented SOD, catalase in plasma and expression of mRNA about procollagens, HAS2 (hyaluronan synthesis 2), MMPs (matrix metalloproteinase) and MITF. The serum SOD and catalase activity were significantly increased PH. The result of procollagen, HAS2 and elastin expression was significantly increased in PH. The gene expression of MMPs (1 and 9) and MITF which is a key factor to synthesis melanin were significantly reduced in PH. The skin hydration exposed to back skin was increased in PH. The winkles, skin thickness and melanin pigment looked like decreased in PL and PH. In conclusion, FSH‐SP decreased the expression of MMPs and MITF increasing the activity of antioxidant enzymes, thereby protecting the skin moisturizing factors and inhibiting melanogenesis. It is believed that effect of the FSH‐SP was reduced to suppress the wrinkle formation, whitening effect and moisturizing.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.