Effect of fruitflow on platelet function: A randomized placebo-controlled clinical trial in middle-aged and elderly subjects

Abstract

• Fruitflow decreased the platelet aggregation rate ex vivo . • Fruitflow reduced the plasma TXB 2 , 6-keto-PGF 1α and PF4 level in subjects. • Fruitflow and aspirin didn’t exert synergistic effect on platelet aggregation. • Fruitflow supplementation for 7 days did not change coagulation. To investigate the effect of fruitflow, a water-soluble tomato extract, on platelet function in participants. 190 participants were completed this clinical trial. The participants were randomly divided into four groups: placebo, fruitflow, aspirin, and fruitflow + aspirin. These groups received the respective supplements for 7 days. Fruitflow intervention for 7 days decreased platelet aggregation ratio by 7.7% and 10.2% in adenosine diphosphate (ADP)- and collagen-stimulated platelets, respectively. Aspirin decreased platelet aggregation ratio by 9.4% and 39% in ADP- and collagen-stimulated platelets, respectively. The combination of fruitflow and aspirin did not exert synergistic inhibitory effect on platelet aggregation. Fruitflow also significantly reduced plasma thromboxane B 2 (TXB 2 ), 6-keto-prostaglandin F 1α (6-keto-PGF 1α ), and platelet factor 4 (PF4) levels. Fruitflow intervention decreased platelet aggregation rate, this suggests that fruitflow is a functional food for reducing platelet activity.