Abstract
Purpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studied in 35 patients with severe combined trauma and 35 post-FFP samples with at least 6-month shelf life. The electrochemical parameters of patients’ blood plasma were analyzed before transfusion, and 1 hr. and 24 hrs. after transfusion.Results. OCP measured in FFP was found to be more positive vs. OCP measured in recipients' blood plasma in 34 out of 35 cases (97%). It has been shown that in patients with severe combined trauma, OCP increased from 5.047 [-7.553; 12.976] mV to 12.827 [-1.372; 24.764] mV and antioxidant activity decreased 24 hours after FFP transfusion from 16.979 [11.302; 20.946] µC to 13.551 [9.288; 18.405] µC. After FFP transfusion, there were no significant changes in clinical blood parameters.Conclusion. By measuring electrochemical parameters of blood plasma in patients with severe combined trauma before and after FFP transfusions, it was discovered that in spite of absence of changes in blood parameters by routine methods, there are changes in the condition of the antioxidant system of the body, which manifest in the bias of patients’ blood plasma OCP towards higher positive values and decreased antioxidant activity. Redox imbalance in the body might cause the oxidative stress development.
Highlights
Трансфузии компонентов крови являются важным компонентом лечения пациентов в критическом состоянии
open circuit potential (OCP) measured in fresh frozen plasma (FFP) was found to be more positive vs. OCP measured in recipients' blood plasma in 34 out of 35 cases (97%)
The purpose of this study is to investigate changes in blood plasma electrochemical parameters in patients with severe combined trauma before and after FFP transfusions
Summary
Трансфузии компонентов крови являются важным компонентом лечения пациентов в критическом состоянии. Переливание крови и ее компонентов широко распространено в клинической практике для лечения пациентов с нарушениями в системе гемостаза. В частности, значительная доля трансфузий приходится на отделения реанимации и интенсивной терапии, где около трети пациентов нуждаются в лечении анемии и коагулопатии [1,2,3]. Для которых гемотрансфузии крайне необходимы, являются пациенты с тяжелой сочетанной травмой, высокий уровень летальности которых связан с массивной кровопотерей [4, 5]. Развитие анемии у пациентов в критическом состоянии связано с кровопотерей, обусловленной травмой, гемодилюцией и частым отбором проб крови. Развитие коагулопатии также связано с кровопотерей, гипоперфузией тканей вследствие травмы, а также с воспалением и острой активацией нейрогуморальной системы [8, 9]
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