Abstract
The maximum number of plateletpheresis donation was permitted up to 24 times every year for each donor in China. This study was investigated the effect of donation frequency on coagulation function of the plateletpheresis donors. A total of 96 plateletpheresis regular donors (splitted into A, B, C groups with 32 donors each group. A was 6–11 times donations, B with 12–17 times and C with 18–24 times) and 32 first time plateletpheresis donors (D group) were analyzed. The coagulation reaction time (R), blood clot formation time (K), α-Angle, normal maximum amplitude (MA) were tested using thromboelastography instrument. Platelet (PLT) count was measured using a hematology analyzer. The ratio of the male to female were 23:9, 24:8, 27:5 and 24:8, the mean age were 40.7 ± 7.6, 39.8 ± 8.3, 40.2 ± 7.9 and 37.0 ± 9.3, and the platelet collection amount were 1.55 ± 0.37 U, 1.58 ± 0.38 U, 1.61 ± 0.33 U and 1.46 ± 0.31 U in the A, B, C, D groups respectively. There were significant difference in the values of the R, K, α-Angle, MA and PLT count between before and after plateletpheresis donation in each group (p < 0.05). However, the values of R, K, α-Angle, MA and PLT count in the before donation were not difference among the A, B, C, D groups (p > 0.05). Similar results were found in the after plateletpheresis donation. The number of the PLT was significantly correlated with the values of the R, K, α-Angle and MA (p < 0.05). However, the frequency of plateletpheresis were not significantly correlated with R, k, α and MA parameters (p > 0.05) using Spearman correlation analysis. The regular donation of apheresis platelets and the frequency of annual blood donation had no adverse effect upon coagulation function of the donors in China.
Highlights
The maximum number of plateletpheresis donation was permitted up to 24 times every year for each donor in China
The values of the R time, k time, a-angle, maximum amplitude (MA), PLT count, mean platelet volume (MPV) and platelet distribution width (PDW) before and after plateletpheresis donation in the each group were listed in the Table 2
Comparison the parameters of the before plateletpheresis donation and plateletpheresis completed in each group respectively, it was showed that the differences of the R time, k time, a-angle, MA, PLT count values between them were significant (p \ 0.05)
Summary
The maximum number of plateletpheresis donation was permitted up to 24 times every year for each donor in China. As the clinical use of plateletpheresis has been increased [3, 4], the contradiction between clinical supply and demand of plateletpheresis has become increasingly prominent due to a limitation of donors To help address this in the USA, the FDA increased the number of maximum donations in a year from 12 to 24 times in 1988 [4]. The maximum annual donations was adjusted in 2011 in China, including the interval of plateletpheresis from 28 to 14 days, and the frequency of annual blood donation from 12 to 24 times according to ‘‘Health examination criteria of blood donor’’ After this adjustment, the frequency of annual plateletpheresis in the donors has increased significantly in China. The characteristics of the donors was collected from the donors, including age, gender, experience of donation, frequency of donation and platelet collection amount
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Indian Journal of Hematology and Blood Transfusion
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
