Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles

Abstract

Encapsulation is a viable and effective technique for protection and stability of vitamin D3 during processing. In the present experiment, the effect of ultrasonication on encapsulation of vitamin D3 using gum arabic was studied. Nanoreduction of gum arabic emulsion largely increased the encapsulation profile of the process. Freeze drying and spray drying methods were employed for the drying of vitamin D3 nanoemulsions to obtain powdered encapsulates. Powders obtained by both techniques were analyzed in terms of physical properties, surface morphology, encapsulation efficiency and in vitro release kinetics. Parameters such as moisture content, product yield, encapsulation efficiency, particle size and zeta potential showed significant difference (p ≤ 0.05). While comparing release behavior, spray dried encapsulates presented better controlled release performance than freeze dried encapsulates. The findings revealed that spray drying technique present a better scope for encapsulating vitamin D3 due to its better encapsulation efficiency and release than freeze drying technique.