Effect of flurbiprofen axetil pretreatment on mesenteric traction syndrome in elderly patients undergoing abdominal surgery

Abstract

Objective To evaluate the effect of flurbiprofen axetil pretreatment on mesenteric traction syndrome in elderly patients undergoing abdominal surgery. Methods Sixty patients of both sexes, aged 65-86 yr, with body mass index of 18.8-25.6 kg/m2, of American Society of Anesthesiologists physical status Ⅰor Ⅱ, scheduled for elective gastrointestinal tract surgery under general anesthesia, were divided into 2 groups(n=30 each)using a random number table: flurbiprofen axetil group(group F)and normal saline group(group NS). Flurbiprofen axetil 50 mg was intravenously injected during anesthesia induction in group F, while the equal volume of normal saline was given instead in group NS.Immediately after anesthesia induction, immediately after mesenteric traction and at 10, 15 and 30 min after mesenteric traction, arterial blood samples were collected for measurement of plasma 6-keto-prostaglandin F1α concentrations using enzyme-linked immunosorbent assay.The occurrence of mesenteric traction syndrome was recorded within 30 min after mesenteric traction. Results Compared with group NS, the plasma 6-keto-prostaglandin F1α concentrations were significantly decreased at each time point, and the incidence of mesenteric traction syndrome was decreased during each period after mesenteric traction in group F(P<0.05). Conclusion Flurbiprofen axetil pretreatment can effectively prevent the development of mesenteric traction syndrome in elderly patients undergoing abdominal surgery. Key words: Flurbiprofen; Aged; Mesenteric traction syndrome