Effect of Flurbiprofen Axetil on Postoperative Analgesia Following Abdominal Surgery: a Single-Center, Prospective Randomized Controlled Trial

Abstract

Flurbiprofen axetil has been proved as an alternative analgesia for postoperative pain. The aim of this study was to investigate the effects of different strategies of flurbiprofen axetil administration on postoperative pain. A total of 160 patients undergoing abdominal surgery were randomly assigned to four groups (n = 40 each): (A) 30 min before the start of surgery, the group was given 1 mg/kg flurbiprofen, then the intravenous patient-controlled analgesia (PCIA) pump contained 0.7μg/kg sufentanil, 1 mg/kg flurbiprofen axetil, 10 mg tropisetron, and 0.4 mg/kg dezocine. (B) The group received 1 mg/kg flurbiprofen axetil before surgical suture, and the PCIA pump was same as group A. (C) The group received no flurbiprofen axetil during operation, but the PCIA pump contained 1 μg/kg sufentanil, 2 mg/kg flurbiprofen axetil, 10 mg tropisetron, and 0.4 mg/kg dezocine. (D) The group was given 1 mg/kg flurbiprofen axetil at 30 min prior to the beginning of surgery and before surgical suture simultaneously, and PCIA pump was the same as group C, but flurbiprofen axetil was not used. Visual Analog Scale at rest/movement (VAS-R/M), sedation score, comfort score, and side effects were observed 48 h postoperatively. Preoperative or intraoperative intravenous flurbiprofen axetil injection decreased the VAS at 8 h, 12 h, and 24 h after surgery compared with postoperative PCIA contained flurbiprofen axetil. VAS scores at rest with intravenous flurbiprofen axetil at 30 min prior to the start of surgery were significantly decreased compared to that before surgical suture at 2 h, 8 h, and 48 h postoperatively. Flurbiprofen axetil ameliorates postoperative pain of patients with abdominal surgery, enhances analgesic effects of sufentanil, and decreases the consumption of sufentanil.