Effect of flurbiprofen axetil for postoperative patient-controlled intravenous analgesia in patients underwent laparoscopic surgery in treating women diseases

Abstract

Objective To evaluate the effect and side effect of postoperative patient-controlled intravenous analgesia with flurbiprofen axetii in patients underwent laparoscopic surgery in treating women diseases. Methods 60 cases of such patients that should be ASA class Ⅰ or Ⅱ were randomly divided into two groups equally with 30 cases each. Fentanyl Group was given fentanyl 500 μg plus oudansetron 8 mg diluted to 100 ml via PCIA after surgery, flurbiprofen Group was administrated fentanyl 250 μg, and flurbiprofen axetil 100 mg plus ondansetron 8mg diluted 100ml via PCIA after surgery, the loading dose was flurbiprofen axetil 50 mg ten minutes prior to the end of the operates. The PCIA rate was 2 ml/h, blous 0.5 ml, lock time 15 min. Analgesia and sedation grade were accessed and side effects were recorded. Results There was no significant difference in analgesia and sedation grade between two groups. The side effects were lower in flurbiprofen Group than those in fentanyl Group. Conclusion Co-administration of flurbiprofen axetil by PCIA offers overall favorable analgesic responses as well as the reduction of fentanyl consumption during PCIA in the patients following laparoscopic surgery. Key words: Laparoacopic surgery in treating women diseases ; Fentanyl ; Flurbiprofen axetil; Analgesia