Effect of fluoride, iodoacetic acid, penicillin, sodium lauroyl sarcosinate and dehydroacetic acid on certain oral bacteria of white rats fed a smooth surface caries diet: preliminary report

Abstract

There have been numerous studies of the oral bacteria of the rat and their relation to the presence of dental caries. A num­ ber of these studies indicate that there are changes in the oral lactobacillus popula­ tion in rats receiving caries potentiating or inhibiting agents.1’8 Since most of these studies have pertained to occlusal caries, it appeared of interest to study the oral flora of rats in relation to the develop­ ment of smooth surface caries. Recently a number of studies have appeared rela­ tive to a type of smooth surface caries produced extensively in white rats par­ ticularly by diets containing processed skim milk powders.9'17 This study pertains, therefore, to certain oral bacteria of rats receiving a cariogenic skim milk powder diet alone, and modified respectively by fluoride, iodoacetate, penicillin, sodium lauroyl sarcosinate (SLS) and dehydro­ acetic acid (D H A ).