Abstract
Background: Hyperlipidemia is a well documented risk factor for atherosclerosis, responsible for significant amount of ischemic strokes and heart disease globally. Studies have shown that vitamin D supplementation with atorvastatin has synergistic effects in lowering serum cholesterol concentrations and ameliorating statin-induced myalgia and myopathy. Aim and objective: To estimate the effect of fixed dose combination of 1000 I.U of Vitamin D3 and Atorvastatin 10mg per day for 3 months on serum HDL, VLDL and Triglyceride values in hyperlipidemic patients compared to those on Atorvastatin 10 mg per day alone. Methodology: The study was a Prospective multiple arm analytical observational study. History and medical details and Data of serum lipid profile investigation, routinely checked at 6 weeks intervals in patients of cardiology department, were collected from the 97 recruited patients for 3 months after obtaining written informed consent from each patient. Results: The results of our study showed a significant reduction in VLDL and Triglyceride Cholesterol values in two study groups at 12 weeks compared to baseline. No significant difference was observed between the two groups. 83% of patients in the study showed a significant elevation of HDL Cholesterol from baseline after 3 weeks of treatment. The mean percentage increase in HDL values from baseline to 3 weeks in Atorvastatin –Vitamin D group showed a significant difference compared with the other group.
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