Abstract
The current study was aimed to find out the effect of figs fruits extracts (FFE) on in vitro rotenone model of Parkinson's disease (PD) by evaluating redox status, mitochondrial membrane potential, cell viability, macromolecule oxidation, and apoptosis. Incubation of SH‐SY5Y cells with rotenone lead neuronal death, mitochondrial dysfunction and DNA fragmentation thorugh redox imbalance, condensation and apoptosis. Rotenone exposure also enhanced the expression of cytochrome C, caspase ‐3, ‐8, ‐9 and Bax (markers of apoptosis) and altered the anti‐apoptotic (Bcl‐2) markers. Reduction of the intracellular reactive oxygen species (ROS) levels ensued due to pretreatment of FFE along with improved antioxidant status, alleviation of rotenone induced mitochondrial dysfunction and apoptosis. Our current findings suggested that figs fruits extracts exhibit the marked neuro‐protective effects, which could be due to its antioxidant, mitochondrial protection and anti‐apoptotic properties. We thus conclude that FFE could be developed as a novel therapeutic molecule for the benefit of reducing the consequences of PD. However, further extensive preclinical and clinical studies are warranted.Support or Funding InformationThe funding support given by Sultan Qaboos University in the form of Internal grant (IG/AGR/FOOD/17/02) to Dr. Mohamed Essa is highly acknowledged.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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