Year-end Sale % OFF 
Abstract
Traditional medicines remain a source of potential for discovering of new compounds with valuable pharmacological activities. Leaves of Ficus carica were dried, powdered and extracted using methanol (ME).An aliquot of ME was dried and re-extracted by water:chloroform and the other aliquot by water: peteruleum ether. Effect of aqueous fractions of the former (ACR; 0.08, 0.1 and 0.13 mg dL -1 ), the latter (APR; 0.07, 0.1 and 0.15 mg dL -1 ) and ME (0.03, 0.05 and 0.08 mg dL -1 ) of Ficus carica leaf on the secretion and cell content of cholesterol in HepG2 cells were studied. Extracts were added to the media in both basal and glucose stimulated conditions and incubated for 48h.While glucose significantly increased cholesterol secretion (17±0.76 mg dL -1 ) vs basal condition (6.91±0.66 mg dL -1 ), co-incubation with extracts reduced secretion of cholesterol in many concentrations of the stimulated condition. On the other hand, cholesterol content of HepG2 in glucose stimulated condition (2.73±0.39 mg dL -1 ) showed significant increase compared to the basal status (1.96±0.14 mg dL -1 ) (p<0.001).Moreover such decrease was shown in response to many concentrations of the extracts. These properties making the hydro-extracts of fig leaf a potentially safe intervention to modulate postprandial hyperlipidemia.
Highlights
Hypercholesterolemia is one of the major risk factors in development of coronary artery disease in recent years[2,6]
We showed ME (0.03, 0.05, 0.08 mg dL-1), aqueous fractions of the former (ACR) (0.08, 0.13 mg dL-1) and CRE (0.07, 0.15mg dL-1) increased cholesterol secretion higher than the basal levels (p
In the most of experiments that have been done by different investigators on animal models, the levels of serum cholesterol have been increased in hypercholestrolemic or hyperlipidemic conditions[8,14,15,19] some studies on streptozotocin or alloxan induced diabetic rats showed an increase in the levels of serum lipids, LDL-C and VLDL-C parameters[4,12,13].On the other hand, some traditional medicines have effective components against to hyperlipidemic conditions
Summary
Hypercholesterolemia is one of the major risk factors in development of coronary artery disease in recent years[2,6]. Nowadays; many non-prescribed treatments have been available for lowering the cholesterol. In this regard, traditional medicines are pursued as alternative drugs for treatment of hypercholesterolemia. Many traditional medicines have been investigated for their therapeutic effects both in humans and in experimental animals[2,12,13,20,21]. The hypocholesterolemic effect of Allium sativum, in human has proved for many years ago[6]. Several therapeutic effects have been shown for different parts of Ficus carica, such as hypoglycemia[18], cancer suppressive[16], anthelmintic[5], hypotriglyceridemia[1,14] hypocholestrolemia[15] and bovine papilomatosis[10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: American Journal of Animal and Veterinary Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
