Abstract
Ethanolic extract of roots of Ficus hispida was investigated in normal and dexamethasone depressed healing conditions, using incision, excision and dead space wound models in albino rats. The root extract of Ficus hispida has shown the maximum breaking strength compared to control group. The rate of epithelialization and wound contraction in excision model was better as compared to control groups. There was significant increase in granulation tissue weight and hydroxyproline content in dead space model compared to control group. The antihealing effect of dexamethasone was also reverted by the administration of ethanolic extract of Ficus hispida in all the wound models .The results indicated that the root extract of Ficus hispida has a significant wound healing activity and also promotes healing in dexamethasone depressed healing conditions.
Highlights
A wound may be defined as a break in the epithelial integrity of the skin or may be defined as a loss or breaking of cellular and anatomic or functional continuity of living tissue (Ramzi et al, 1994)
The ethanolic root extract showed a promising reversal of dexamethasone depressed healing in rats by increasing the breaking strength in incision wound model (Group 4)
In dead space wound model, the ethanolic extract significantly increased the hydroxyproline content, which is a marker of collagen content and of the healing process (Table I)
Summary
A wound may be defined as a break in the epithelial integrity of the skin or may be defined as a loss or breaking of cellular and anatomic or functional continuity of living tissue (Ramzi et al, 1994). Some plants possessing pro-healing activity have been scientifically analyzed. The wound healing potential of Tridax procumbens (Udupa et al, 1995), Trigonella foenumgraecum (Taranalli, Kuppast, 1996), Leucas lavandulaefolia (Saha et al, 1997), Aloe vera (Chitra et al, 1998), Ageratum conyzoides (Chah et al, 2006), Dendrophthoe falcate (Pattanayak et al, 2008) and Heliotropium indicum, Plumbago zeylanicum, Aca-. Panchal lypha indica (Reddy et al, 2002) have shown promising healing activity
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