Abstract
Background Fibrinogen supplementation in trauma has been suggested in order to restore or improve haemostatic competence; this could possibly reduce or replace the need for transfusions in case of bleeding. Results from functional haemostatic assays indicate that lowered clot strength is associated with a risk for massive transfusions [1]. The optimal fibrinogen concentration or indications for supplementation in trauma patients have not been established [2].
Highlights
Fibrinogen supplementation in trauma has been suggested in order to restore or improve haemostatic competence; this could possibly reduce or replace the need for transfusions in case of bleeding
Eleven patients with severe injury admitted to a Danish level 1 trauma centre were enrolled in the study
Eight out of eleven patients received a transfusion within 12h after hospital admission
Summary
Fibrinogen supplementation in trauma has been suggested in order to restore or improve haemostatic competence; this could possibly reduce or replace the need for transfusions in case of bleeding. Aim To examine the in vitro effect of adding fibrinogen concentrate to whole blood from trauma patients by Thrombelastography (TEG). Methods Eleven patients with severe injury admitted to a Danish level 1 trauma centre were enrolled in the study.
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