Effect of Ferula persica plant methanol extract on the level of Cox-2 in induced squamous cell carcinoma (SCC) in rat tongue.

Sepideh Vosoughhosseini,Mehran Mesgari,Ali Barzegar,Parya Emamverdizadeh,Amirala Aghbali,Mohammad Razbani

doi:10.15171/joddd.2018.014

Sepideh Vosoughhosseini, Mehran Mesgari + Show 4 more

Open Access

https://doi.org/10.15171/joddd.2018.014

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Abstract

Background: More than 90% of oral cancers are cases of squamous cell carcinoma. Standard treatment of cancer includes a combination of surgery, chemotherapy and radiotherapy. Each of these treatments, however, brings about certain problems and side effects. Today herbal medicine, has become a more preferable option in dealing with health problems or preventing them because this type of medicine has better compatibility with the body and does not cause undesirable side effects. In this study , the effect of Ferula persica plant methanol extraction on Cox-2 levels in SCC induced rat tongue is conducted in vivo. Methods: In this lab research, 75 rats from SD race in the age – range of 2/5 – 3 months were selected and put in five groups. In order to induce tongue carcinoma, 4– Nitroquinoline 1 (4 NQO) powder was used 3 times a week for each rat. Furthermore, Ferula persica extract was given to each of the groups in order to examine Cox-2 changes in the blood. Results: Comparison of Cox-2 average in various groups resulted in the observation that there was significant difference between the Cox-2 levels in the groups which had only received carcinogen and the other groups. In this group, Cox-2 level was less and in the group that had received Ferula extract (500 mg) along with carcinogen , Cox-2 level was found to be more than other groups. Conclusion: Ferula persica extract does not have reducing effect on serum Cox-2.

Highlights

Oral cancer is one of the most common neoplasms in the world
More than 90% of oral cancers are cases of squamous cell carcinoma. This type of cancer has the highest mortality rate: almost half of the people suffering from it live more than 5 years after the onset of the disease.2,3In various studies on the etiology of oral cancers, it has been observed that Cox-2 has high expression in oral cancers and precancerous lesions and it seems to be one of the agents involved in the etiology of oral lesions
75 rats (5 groups of 15 rats) of SD race were used; 50,250 and 500 mg/kg concentrations of Ferula persica extract dissolved in distilled water were injected through an intraperitoneal technique to the mice groups A, B and C

Summary

Introduction

Various factors lead to oral cancers.[1] More than 90% of oral cancers are cases of squamous cell carcinoma. This type of cancer has the highest mortality rate: almost half of the people suffering from it live more than 5 years after the onset of the disease.2,3In various studies on the etiology of oral cancers, it has been observed that Cox-2 has high expression in oral cancers and precancerous lesions and it seems to be one of the agents involved in the etiology of oral lesions. Standard treatment of cancer includes a combination of surgery, chemotherapy and radiotherapy Each of these treatments, brings about certain problems and side effects. The effect of Ferula persica plant methanol extract on Cox-2 levels in SCC induced in rat tongue was evaluated in vivo

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Conclusion