Effect of Feeding Pyridine Derivatives to Young Rats on a High Protein Diet

Abstract

Summary1. The effect of the ingestion of a series of pyridine derivatives by immature rats on a high protein diet is described.2. None of the N-methyl derivatives of this series had any appreciable influence on either the fat content or the absolute liver weight.3. Gamma picoline, nicotinic acid, and nicotinamide produced slight increase in liver fat; beta picoline and coramine produced significant increases in liver fat. In the case of beta picoline and coramine this increase in fat could be prevented by the inclusion of 1.2% methionine or 0.5% choline. The effect of methionine or choline on the metabolism of the other compounds reported was not determined. 4. Coramine produced a great increase in the fat-free liver weight which could not be prevented by the addition of choline or methionine to the diet. 5. The growth inhibition following the administration of beta picoline or coramine was not appreciably affected by the addition of choline or methionine to the high protein diet.