Abstract
The aim of this study was to evaluate the effect of feed restriction followed by a realimentation with monensin supplementation on morphological, ultrastructural, and apoptotic characteristics in the term placenta of Anglo-Nubian does. Treatments were a control group (C = 5), a group fed at 0.70 of that consumed by controls (R = 7), and the same as R with monensin (M = 7). After parturition, 27 placentas were gathered, C: 7, M: 10, and R: 10. No differences were detected between treatments in relation to morphological and ultrastructural analysis. The greatest values of binucleate cells were detected in placentas from R, and it could be due to the need to compensate and satisfy nutritional differences of restriction. We detected the highest apoptotic index in R as a consequence of nutritional treatment. We describe for the first time the structural and ultrastructural morphology and remodeling by apoptosis of Anglo-Nubian placenta at term of goats subjected to nutritional restriction during peripubertal period and the use of monensin as a growth promoter.
Highlights
Caprine placenta is classified as cotyledonary and characterized by the development of restricted areas of interdigitation between fetal and maternal tissues known as placentomes [1]
Mean placental weight was 457 ± 140.6 g, and no differences were detected between groups for this variable neither for cotyledon number nor for placental efficiency (Table 1)
The results of this study show positive correlations between cotyledon number (CN), placental efficiency (PE), cotyledon density (CD), and litter weight (LW) (r = 0.6, 0.53, and 0.58)
Summary
Caprine placenta is classified as cotyledonary and characterized by the development of restricted areas of interdigitation between fetal and maternal tissues known as placentomes [1]. This placenta has been classified as synepitheliochorial due to the occurrence of migration of fetal chorionic binucleate cells across the microvillar junction to fuse with the maternal epithelial cells and to form the syncytium [2]. Binucleate cells are involved in villi development [4] and are a unique feature in ruminants [5] In caprines, their role in maturation and delivery of placenta is yet unknown [6]
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