Abstract
We aimed to evaluate the effect of fat grafting on postoperative intraabdominal adhesions by promoting mesothelial healing on a rat model. Thirty Wistar albino rats were grouped as control and fat grafted group. They all underwent laparotomy, anterior cecal wall abrasion and peritoneal injury. On postoperative day 14, all surviving rats were sacrificed and adhesions, fibrosis and inflammation were graded using quantitative scoring systems. Fat grafting significantly reduced adhesion formation compared to the control group (p<0.002), less fibrosis (p<0.025) and less inflammation (p<0.024). Autologous intraperitoneal fat grafting promotes mesothelial healing in serosal and peritoneal injury rat model. The present study underlines the benefits of the pluripotent stem cell reservoir fat tissue and points to a new area of use. Results are promising for reducing adhesions, adhesion related morbidities and cost burden via a simple, cheap and applicable method; autologous fat grafting.
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