Abstract
Washed mouse platelets produced thromboxane B 2 (TXB 2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB 2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB 2 and 12-HETE production in both the control and diabetic groups.
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