Abstract
The structure, dynamics and organization of cell membranes are not passive consequences of lipid equilibration in a two-dimensional milieu. Instead, a rapidly advancing body of work now suggests that these physical properties are actively and spatiotemporally regulated by a variety of intrinsic and extrinsic constraints. Extrinsic constraints, or interfacial templating, involve dynamics and fluctuations in the underlying cytoskeleton and cytoskeleton-binding membrane proteins, which actively re-compartmentalize the membrane fluid, modulating molecular diffusion and organization in membrane bilayers.
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