Abstract
Objective: The present study was aimed to investigate the effects of the aqueous extract of rhizome of phragmites australis on carbohydrate metabolism, some enzyme activities and pancreatic tissue in alloxan induced diabetic rats.Methods: Wistar rats were divided into three groups (n=6) as control, diabetic group and test groups (Diabetic+AEPA). Diabetes in rats was induced by alloxane using a single peritoneal injection of 150 mg/kg dose. Aqueous extract of Phragmites australis was supplemented (200 mg/kg b. w) orally for three weeks. The aqueous extract of Phragmites australis was prepared and phytochemical were analyzed by using standard methods. Blood glucose level, pancreas histology and various biochemical parameters were assessed.Results: The results of the phytochemical analysis of aqueous extract of Phragmites australis (AEPA) revealed the presence of tannin, terpenoids, glycosides and flavonoids. Compared with the control, a significant decrease in the body weight gain (p<0.01) and increase in food intake (p<0.001) were noticed in the diabetic group. The biochemical evaluation showed significantly higher values for glucose (p<0.001), lipid profile (p<0.05), transaminases (p<0.05), amylase and alkaline phosphatase (p<0.001) activities in diabetic group compared with the control. Histology of the pancreas showed congestion of vessels and focal area of necrosis in diabetic untreated rats. However, treatment with aqueous extract of Phragmites australis significantly normalized blood glucose, serum biochemical profile and pancreas histomorphology.Conclusion: It is suggested that aqueous extract of Phragmites australis exhibits a benefic effect in rat to a great extent in attenuating and restoring the damage sustained by diabetes.
Highlights
Diabetes mellitus is a global health crisis, which has been affecting the humanity irrespective of the socio-economic profile and geographic location of the population [1]
The promising preliminary results reported with the use of Phragmites australis in disease components of metabolic syndrome have prompted us to investigate the effect of aqueous extract from rhizome of Phragmites australis on carbohydrate metabolism, some enzymes activities and pancreatic tissue in alloxan induced diabetic rats, which is an important contributor to the metabolic syndrome
Induction of type 1 diabetic state caused a decrease (p
Summary
Diabetes mellitus is a global health crisis, which has been affecting the humanity irrespective of the socio-economic profile and geographic location of the population [1]. Therapy has been based on insulin or drugs that stimulate insulin secretion (sulphonylureas and rapid-acting secretagogues), reducing hepatic glucose production (biguanides), delaying digestion and absorption of intestinal carbohydrate (alphaglucosidase inhibitors), or improving insulin action in thiazolidinedione’s [4]. All of these therapies have various side effects such as gastrointestinal upset, weight changes, hypoglycemia, joint stiffness, kidney complications, and skin alterations [5]. Some of the plants which are being used for the treatment of diabetes have received scientific or medicinal scrutiny and even the world health organization (WHO) expert committee on diabetes recommends that this area warrant further attention [8]. The promising preliminary results reported with the use of Phragmites australis in disease components of metabolic syndrome (like Hepatoprotective and antioxidant activities) have prompted us to investigate the effect of aqueous extract from rhizome of Phragmites australis on carbohydrate metabolism, some enzymes activities and pancreatic tissue in alloxan induced diabetic rats, which is an important contributor to the metabolic syndrome
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmacy and Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
