Effect of extract gel of Sargassum sp. against histopathological of the number of fibroblast cells in the burn healing process

Abstract

Introduction: Burns are injuries caused by heat and cause damage to the skin. Burns are characterized by red, peeling skin. Burns must be treated properly so that wound healing can close completely. In Indonesia, seaweed is a promising commodity. From 5.2 million wet tons in 2011 to 9.2 million tons in 2013, seaweed output increased by 76.4 percent in Indonesia. This study aimed to study the histopathological picture of burn tissue given Sargassum sp. Methods: An experimental study design with a randomized post-test-only control group design was used for this study. White mice (Mus musculus), the study's population, made up this group. The study was divided into 4 treatment groups. The results of the calculation of the number of fibroblast cells were then evaluated using statistical tests to determine differences between groups. Data analysis was carried out using SPSS ver. 25 with a One-Way ANOVA test. Results: The mean result of fibroblast cell count in group 1 (plain gel) was 36.14 PLP, group 2 (Sargassum sp. 5%) was 51.28 PLP, group 3 (Sargassum sp. 10%) was 53.36 PLP and group 4 (Sargassum sp. bioplacenton) 20.05 PLP. The results of the statistical test showed that there was a significant difference between groups with a p-value of 0.03 (<0.05). Conclusion: The results of the histology show that there is a potential content of Sargassum sp. to affect wound healing.