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Abstract
Effect of exogenously added soybean phosphatidylinositol on c- myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c- myc unexpressed cells was reduced, while that of c- myc expressed cells was not. Death of c- myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca 2+, and it seemed to be related to reduction of protein kinase C activity.
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