Abstract
Results are reported for serial determinations of creatine concentration in the erythrocytes of cancer patients undergoing radiotherapy, and in erythrocytes, plasma, and urine of sham-irradiated rats and in rats exposed to doses of 500, 1000, or 1500 r x radiation. The concentration of creatine in erythrocytes of the patients rose after 2 to 3 weeks of radiotherapy. The erythrocytic creatine concentrations rose only in the sham-irradiated rats and in rats exposed to 500 and 1000 r, whereas in rats exposed to 1500 r a marked fall in erythrocytic concentration of creatine occurred. The response observed in sham-irradiated tats was attributed to restraint during sham-irradiation. (C.H.)
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