Effect of exposure of recurrent laryngeal nerve on glialcellline-derived neurotrophic factor expression in thyroid lobectomy

Abstract

Objective To study the effect of exposure of recurrent laryngeal nerve (RLN) on glialcellline-derived neurotrophic factor(GDNF) expression in thyroid lobectomy. Methods A total of 120 patients with thyroid diseases from February 2016 to March 2017 were divided into control group and resarch group according to random number table, with 60 cases in each group. They were autreated with thyroid lobectomy. The patients in control group had no exposure of RLN, while the patients in research group had exposure of RLN. The RLN injury and GDNF levels were compared between the two groups. Results The postoperative GDNF level of the research group and the control group were (738.61±15.98) ng/L and (698.32±13.12) ng/L, there was significant difference (P<0.05). After surgery, the RNL injury rate of research group was lower than that of control group, there was significant difference(P<0.05). Conclusions Exposure of RLN in thyroid lobectomy can reduce the effect on GDNF level and the postoperative RNL injury rate, and protect the RNL. Key words: Thyroid; Recurrent laryngeal nerve; Glialcellline-derived neurotrophic factor