Abstract
The rate of incorporation of [2- 3H]myo-inositol into phosphatidylinositol was found to be significantly decreased in sciatic nerve from both alloxan and streptozotocin-diabetic rats. The rates of incorporation into phospholipid of tritiated serine and ethanolamine were unchanged while choline showed an upward trend in sciatic nerve from alloxan-diabetic rats. Insulin added in vitro significantly increased [2- 3H]myo-inositol incorporation into phospholipids by normal rat sciatic nerve; only small changes were recorded with high concentrations of glucose, and galactose. The results are discussed in relation to the physiological functions of phosphatidylinositol and the role of free myo-inositol in the regulation of cellular processes.
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