Abstract
Intestinal absorption of poorly-absorbable sulfanilic acid was investigated in rats with acute renal failure by an in situ loop method. The acute renal failure was induced by an intramuscular injection of HgCl2 or 50% glycerol, or by 5/6 nephrectomy. The mean blood urea nitrogen in the experimental group at the time of evaluation of intestinal absorption was significantly higher than in the control groups (normal or laparotomized). Absorption of sulfanilic acid by the small intestine was significantly increased in all renal failure groups examined, but it was unchanged in the laparotomy group. Reduction of barrier function in the intestinal mucosa during renal failure is indicated.
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