EFFECT OF EXOGENOUS NITRIC MONOXIDE THERAPY ON IMMUNOLOGICAL PARAMETERS IN BISPHOSPHONATE OSTEONECROSIS OF THE JAWS

Abstract

Bisphosphonate osteonecrosis of the jaw (BONCH) is a drug-induced osteonecrosis in patients with a history of malignancies. It is characterized by progressive destruction of the jawbone with the development of a chronic inflammatory process in the parotid tissues. For the treatment of the disease, the use of exogenous nitrogen monoxide (NO) synthesized using the Plason device is proposed. The study of immunological parameters in patients with BONCH in the main group (n = 26), who received NO-therapy, and in the comparison group (пи = 27), who received traditional sanitation with 0,05 % chlorhexidine bigluconate. The dynamics of indicators in the main group - a decrease in the activity of the cellular link (activity of phago-quoting granulocytes and monocytes) to normal values, an increase in the intensity of local immunity (IgA) and a decrease in the concentration of humoral factors of acute (IgM) and chronic (IgG) inflammation p < 0,05) - confirms the anti-inflammatory and immunomodulatory effect of exogenous NO therapy. In the case of the comparison group, reducing only one indicator (AFM) to normal values does not allow us to prove the effect of traditional sanitation on immunological parameters in General. Thus, the use of exogenous nitrogen monoxide for patients with BONCH is justified both at the stage of preoperative preparation and as a basic conservative therapy if surgical treatment is not possible.